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Quitter is a Twitter client that doesn't announce itself to the entire cube farm; it runs in a command window (or "DOS window"). There's no installer and no entries in the Start Menu; it will run from a thumbdrive. It's a single small EXE file (about 105k) and it stores its settings in a small XML file. With Quitter, you.
Freeware download of Quitter 1.0.0, size